Frequency domain properties and fundamental limits of buffer–feedback regulation in biochemical systems

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Frequency Domain Properties and Fundamental Limits of Buffer-Feedback Regulation in Biochemical Systems

Feedback regulation in biochemical systems is fundamental to homeostasis, with failure causing disease or death. Recent work has found that cooperation between feedback and buffering—the use of reservoirs of molecules to maintain molecular concentrations—is often critical for biochemical regulation, and that buffering can act as a derivative or lead controller. However, buffering differs from d...

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ژورنال

عنوان ژورنال: Automatica

سال: 2019

ISSN: 0005-1098

DOI: 10.1016/j.automatica.2019.02.017